Cannabidiol Mitigates Opioid Reward On Conditioned Place Preference In Mice

Markos, James Roland (2017) Cannabidiol Mitigates Opioid Reward On Conditioned Place Preference In Mice. Undergraduate thesis, under the direction of Kenneth Sufka from Psychology, University of Mississippi.

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ABSTRACT This study sought to determine whether the cannabis constituent, cannabidiol (CBD), is able to attenuate morphine reward in the conditioned place preference (CPP) paradigm. Mice received IP injections of either saline or morphine and increasing doses of CBD that were paired with a distinct environment in the CPP apparatus. Morphine-produced place preference was dose-dependently blocked by CBD. Furthermore, none of the tested doses of CBD exhibited reward or aversion. The finding that CBD blocks opioid reward suggests CBD may be useful as an abuse deterrent, particularly in the setting of opioid use for pain management.

Item Type: Thesis (Undergraduate)
Creators: Markos, James Roland
Student's Degree Program(s): B.S. in Biological Sciences, B.A. in Public Policy Leadership and Biochemistry
Thesis Advisor: Kenneth Sufka
Thesis Advisor's Department: Psychology
Institution: University of Mississippi
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RM Therapeutics. Pharmacology
Depositing User: JR Markos
Date Deposited: 10 May 2017 19:34
Last Modified: 10 May 2017 19:34

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