Markos, James Roland (2017) Cannabidiol Mitigates Opioid Reward On Conditioned Place Preference In Mice. Undergraduate thesis, under the direction of Kenneth Sufka from Psychology, University of Mississippi.
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Abstract
ABSTRACT This study sought to determine whether the cannabis constituent, cannabidiol (CBD), is able to attenuate morphine reward in the conditioned place preference (CPP) paradigm. Mice received IP injections of either saline or morphine and increasing doses of CBD that were paired with a distinct environment in the CPP apparatus. Morphine-produced place preference was dose-dependently blocked by CBD. Furthermore, none of the tested doses of CBD exhibited reward or aversion. The finding that CBD blocks opioid reward suggests CBD may be useful as an abuse deterrent, particularly in the setting of opioid use for pain management.
| Item Type: | Thesis (Undergraduate) |
|---|---|
| Creators: | Markos, James Roland |
| Student's Degree Program(s): | B.S. in Biological Sciences, B.A. in Public Policy Leadership and Biochemistry |
| Thesis Advisor: | Kenneth Sufka |
| Thesis Advisor's Department: | Psychology |
| Institution: | University of Mississippi |
| Subjects: | B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry R Medicine > RM Therapeutics. Pharmacology |
| Depositing User: | JR Markos |
| Date Deposited: | 10 May 2017 19:34 |
| Last Modified: | 10 May 2017 19:34 |
| URI: | http://thesis.honors.olemiss.edu/id/eprint/781 |
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