Staszko, Stephanie (2014) Modeling Nitroglycerin-Induced Migraine in Rats. Undergraduate thesis, under the direction of Kenneth Sufka from Psychology, University of Mississippi.
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Abstract
The present research sought to determine whether nitroglycerin (NTG) produced changes in clinically relevant endophenotypes of migraine. Rats were given a single injection of NTG or vehicle with the following dependent measures recorded: Rat Grimace Scale, hot and cold tail flick latency, Rotor-Rod performance, and photophobia and movement in traditional and modified light/dark boxes. NTG increased rat grimace scores but did not produce thermal allodynia nor photophobia. Further, NTG produced paradoxical increases in Rotor-Rod performance and movement. These results demonstrate that a single injection of NTG does not produce behaviors that parallel clinical symptoms of migraine.
| Item Type: | Thesis (Undergraduate) |
|---|---|
| Creators: | Staszko, Stephanie |
| Student's Degree Program(s): | B.A. in Biology and Psychology |
| Thesis Advisor: | Kenneth Sufka |
| Thesis Advisor's Department: | Psychology |
| Institution: | University of Mississippi |
| Subjects: | B Philosophy. Psychology. Religion > BF Psychology R Medicine > RM Therapeutics. Pharmacology |
| Depositing User: | Stephanie Staszko |
| Date Deposited: | 29 Apr 2014 13:50 |
| Last Modified: | 29 Apr 2014 13:50 |
| URI: | http://thesis.honors.olemiss.edu/id/eprint/40 |
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