Modeling Nitroglycerin-Induced Migraine in Rats

Staszko, Stephanie (2014) Modeling Nitroglycerin-Induced Migraine in Rats. Undergraduate thesis, under the direction of Kenneth Sufka from Psychology, University of Mississippi.

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The present research sought to determine whether nitroglycerin (NTG) produced changes in clinically relevant endophenotypes of migraine. Rats were given a single injection of NTG or vehicle with the following dependent measures recorded: Rat Grimace Scale, hot and cold tail flick latency, Rotor-Rod performance, and photophobia and movement in traditional and modified light/dark boxes. NTG increased rat grimace scores but did not produce thermal allodynia nor photophobia. Further, NTG produced paradoxical increases in Rotor-Rod performance and movement. These results demonstrate that a single injection of NTG does not produce behaviors that parallel clinical symptoms of migraine.

Item Type: Thesis (Undergraduate)
Creators: Staszko, Stephanie
Student's Degree Program(s): B.A. in Biology and Psychology
Thesis Advisor: Kenneth Sufka
Thesis Advisor's Department: Psychology
Institution: University of Mississippi
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RM Therapeutics. Pharmacology
Depositing User: Stephanie Staszko
Date Deposited: 29 Apr 2014 13:50
Last Modified: 29 Apr 2014 13:50

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