Davis, Morgan Elizabeth (2014) The Effect of Sumatriptan on Clinically Relevant Behavioral Endpoints in a Recurrent Nitroglycerin Migraine Model in Rats. Undergraduate thesis, under the direction of Kenneth Sufka from Psychology, The University of Mississippi.
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Abstract
The present research sought to determine the effects of sumatriptan on clinically relevant behavioral endpoints in migraine produced by repeated nitroglycerin (NTG) administrations in rats. Rats were given 5 NTG administrations each of which was followed by either saline, 0.3 mg/kg sumatriptan, or 1.0 mg/kg sumatriptan over a 2-week period. During their 5th NTG migraine episode, behavioral endpoints were the Rat Grimace Scale, photophobia, and movement. Sumatriptan dose dependently attenuated a) loss in weight, b) elevated Rat Grimace Scale pain scores, and c) decreased movement in the modified light-dark box. In addition, rats with the highest dose of sumatriptan tended to spend more time in the light portion of the light-dark box. We conclude from this study that sumatriptan is effective in reversing behavioral endpoints that parallel clinical symptoms of human migraineurs. These findings further validate the recurrent NTG migraine model as a clinically relevant simulation of human migraine that can be used as a drug-screening tool for novel therapeutics.
| Item Type: | Thesis (Undergraduate) |
|---|---|
| Creators: | Davis, Morgan Elizabeth |
| Student's Degree Program(s): | B.S. in Chemistry |
| Thesis Advisor: | Kenneth Sufka |
| Thesis Advisor's Department: | Psychology |
| Institution: | The University of Mississippi |
| Subjects: | B Philosophy. Psychology. Religion > BF Psychology R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology |
| Depositing User: | Morgan Davis |
| Date Deposited: | 07 May 2015 16:21 |
| Last Modified: | 07 May 2015 16:21 |
| URI: | http://thesis.honors.olemiss.edu/id/eprint/380 |
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