Neurotoxicity of Asimina Triloba

Sanders, Myriam (2018) Neurotoxicity of Asimina Triloba. Undergraduate thesis, under the direction of Nicole Ashpole from BioMolecular Sciences, University of Mississippi.


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Neurodegenerative diseases are thought to be brought on by genetic and environmental factors including exposure to compounds and extracts found in plants. Many substances extracted from plants have been shown to induce cell death in neurons. This experiment tests different plant compounds to determine if they induce death in neurons in cell culture. In particular, we focused on extracts and compound from the Asimina Triloba plant- a plant that had anecdotally been connected with Parkinson’s Disease-like effects. Cultured neurons were treated with increasing concentrations of the compounds and extracts. Twenty-four hours after treatment, viability was assessed. Results show that while most of the compounds and extracts do not induce neurotoxicity, some of the compounds and extracts are neurotoxic and become increasingly more neurotoxic as the concentration of the compounds increase. In the future, it is important to continue exploring the toxicity of this fruit to determine whether consumption is detrimental to neuronal health. Moreover, future studies may elucidate whether these compounds could be used to model degeneration.

Item Type: Thesis (Undergraduate)
Creators: Sanders, Myriam
Student's Degree Program(s): Biology
Thesis Advisor: Nicole Ashpole
Thesis Advisor's Department: BioMolecular Sciences
Institution: University of Mississippi
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Depositing User: Myraim Sanders
Date Deposited: 07 May 2018 17:00
Last Modified: 07 May 2018 17:00

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