Validation of a Recurrent Nitroglycerin Migraine Model in the Rat

Johnson, Ainslee (2014) Validation of a Recurrent Nitroglycerin Migraine Model in the Rat. Undergraduate thesis, under the direction of Kenneth Sufka from Psychology, University of Mississippi.

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Abstract

The present research sought to determine if repeated nitroglycerin (NTG) administrations elicited responses on clinically relevant behavioral endpoints of migraine in rats. Rats were given five saline, three NTG or five NTG administrations over a two-week period. After their fifth injection rats were evaluated using the rat grimace scale, modified light/dark box, thermal tail flick tests, elevated plus maze and forced swim test. Repeated NTG administration affected weight gain, movement in the modified light/dark box and photophobia. The thermal tail flick tests, elevated plus maze and forced swim test did not reveal treatment effects. Based on these findings, we conclude that the recurrent NTG migraine model is a valid and clinically relevant simulation of human migraine.

Item Type: Thesis (Undergraduate)
Creators: Johnson, Ainslee
Student's Degree Program(s): B.A. in Psychology
Thesis Advisor: Kenneth Sufka
Thesis Advisor's Department: Psychology
Institution: University of Mississippi
Subjects: >
Depositing User: Ainslee Johnson
Date Deposited: 08 May 2014 19:28
Last Modified: 07 Jun 2016 19:19
URI: http://thesis.honors.olemiss.edu/id/eprint/97

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