Psammaplins Selectively Target Triple-Negative Metastatic Breast Tumor Cells that are Genetically Programmed to Colonize Specific Organs

Le, Thuy Phuong T. (2017) Psammaplins Selectively Target Triple-Negative Metastatic Breast Tumor Cells that are Genetically Programmed to Colonize Specific Organs. Undergraduate thesis, under the direction of Yu-Dong Zhou from Chemistry & Biochemistry, The University of Mississippi.

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Abstract

Five bromotyrosine-derived marine sponge metabolites, four psammaplins (1 – 4) and the psammaplin dimer, bisaprasin (5) were isolated from a lipid extract sample of the marine sponge Dendrilla lacunosa.  Psammaplins act as histone deacetylase (HDAC) inhibitors that alter cellular gene expression.  The D. lacunosa psammaplins activated the oxygen regulated transcription factor HIF-1 (hypoxia-inducible factor-1) in T47D human breast tumor cells and displayed cell line specific effects against aggressive organotropic metastatic cell lines that were derived from triple-negative MDA-MB-231 human breast tumor cells.

Item Type: Thesis (Undergraduate)
Creators: Le, Thuy Phuong T.
Student's Degree Program(s): B.A. in Biochemistry
Thesis Advisor: Yu-Dong Zhou
Thesis Advisor's Department: Chemistry & Biochemistry
Institution: The University of Mississippi
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Depositing User: Thuy Phuong Le Le
Date Deposited: 15 May 2017 18:29
Last Modified: 15 May 2017 18:29
URI: http://thesis.honors.olemiss.edu/id/eprint/925

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