A Study of the Hydrophobic Interactions Between Twenty-three CB1 Selective JWH Compounds and an Active-State CB1 Receptor Model to Discover Key Structural Features of the JWH Compounds and Key Protein Residues of the CB1 Receptor

Reliquias, Lyncyn Louise (2017) A Study of the Hydrophobic Interactions Between Twenty-three CB1 Selective JWH Compounds and an Active-State CB1 Receptor Model to Discover Key Structural Features of the JWH Compounds and Key Protein Residues of the CB1 Receptor. Undergraduate thesis, under the direction of Murrell Godfrey from Chemistry and Biochemistry, The University of Mississippi.

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Abstract

Synthetic cannabinoids, commonly found in Spice, have recently become a popular substitute for marijuana as they have similar effects to THC, the most powerful constituent of marijuana. Additionally, they are increasingly becoming a source of drug abuse as they cannot be detected with normal drug test screenings. This study specifically analyzed a total of twenty-three CB1 selective JWH compounds and their hydrophobic interactions with an active-state CB1 receptor model. The ligands were categorized per their structural similarities, and this study was aimed to find patterns within each structural moiety that would lead to the discovery of key structural features and/or protein residues of the CB1 receptor. The results of this study will be utilized to predict potential synthetic cannabinoids and to create a database of those structures to expedite the process of identifying them and recognizing their interactions with the CB1 receptor.

Item Type: Thesis (Undergraduate)
Creators: Reliquias, Lyncyn Louise
Student's Degree Program(s): B.A. Biochemistry
Thesis Advisor: Murrell Godfrey
Thesis Advisor's Department: Chemistry and Biochemistry
Institution: The University of Mississippi
Subjects: Q Science > QD Chemistry
Depositing User: Lyncyn Louise Reliquias
Date Deposited: 12 May 2017 15:14
Last Modified: 12 May 2017 15:14
URI: http://thesis.honors.olemiss.edu/id/eprint/891

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