Spectroscopic and Computational Studies of the Hydrogen Bonding Interactions of Hydroxyethyl Ethers

Williams, Ashley Elizabeth (2017) Spectroscopic and Computational Studies of the Hydrogen Bonding Interactions of Hydroxyethyl Ethers. Undergraduate thesis, under the direction of Nathan Hammer from Chemistry and Biochemistry, The University of Mississippi.

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Abstract

The isoenzymatic form of microsomal cytochrome P450, CYP2E1, is involved in the formation of oxygen free radicals, specifically hydroxyethyl ether. Chronic alcohol abuse has been found to induce larger levels of CYP2E1 in the liver, thus increasing production of these harmful free radicals. Generation of the hydroxyethyl ether oxygen free radicals occurs during the metabolism of ethanol in microsomes. The hydrogen-bonding interactions of hydroxyethyl ethers with water have yet to be analyzed, and information regarding the interactions with water can be applied directly to biological systems. Here, we employ Raman spectroscopy and computational chemistry to study hydroxyethyl ether complexes in micro-solvated networks of varying complexity.

Item Type: Thesis (Undergraduate)
Creators: Williams, Ashley Elizabeth
Student's Degree Program(s): B.S. Chemistry (Biochemistry track)
Thesis Advisor: Nathan Hammer
Thesis Advisor's Department: Chemistry and Biochemistry
Institution: The University of Mississippi
Subjects: Q Science > QD Chemistry
Depositing User: Ashley Williams
Date Deposited: 11 May 2017 17:13
Last Modified: 11 May 2017 17:13
URI: http://thesis.honors.olemiss.edu/id/eprint/833

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