Design and Synthesis of Sigma-1 Probe for Positron Emission Tomography (PET) Imaging

Ly, May (2015) Design and Synthesis of Sigma-1 Probe for Positron Emission Tomography (PET) Imaging. Undergraduate thesis, under the direction of Christopher McCurdy from Biomolecular Sciences, University of Mississippi School of Pharmacy.

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Abstract

Sigma-1 receptor radioligands have the potential to detect and monitor various neurological diseases. Because sigma-1 receptors are believed to be associated with numerous psychiatric conditions and neurodegenerative diseases, radioligands for sigma-1 receptors have the potential to serve as novel diagnostic tools and may be useful in assessing treatment effectiveness. A benzothiazolone 18F-labeled sigma-1 receptor ligand, CM304, has demonstrated promise as a specific positron emission tomography radiotracer for visualizing sigma-1 receptors in living subjects. Based on CM304, backup molecules were created to improve the overall drug profile, including half- life and bioavailability.

Item Type: Thesis (Undergraduate)
Creators: Ly, May
Student's Degree Program(s): B.S. in Pharmaceutical Sciences
Thesis Advisor: Christopher McCurdy
Thesis Advisor's Department: Biomolecular Sciences
Institution: University of Mississippi School of Pharmacy
Subjects: R Medicine > RS Pharmacy and materia medica
Depositing User: May Ly
Date Deposited: 29 Apr 2015 13:32
Last Modified: 29 Apr 2015 13:32
URI: http://thesis.honors.olemiss.edu/id/eprint/270

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