Targeting Metastatic Breast Cancer with Statin Drugs and CoQ10

Thrasher, Jacob (2018) Targeting Metastatic Breast Cancer with Statin Drugs and CoQ10. Undergraduate thesis, under the direction of Yu-Dong Zhou and Dale Nagle from Chemistry and Biochemistry and BioMolecular Sciences, University of Mississippi.

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Abstract

Statin drugs are commonly prescribed to lower cholesterol levels in patients, but recently statins have been under investigation as a potential anti-cancer drug. Statins are HMG-CoA reductase inhibitors and subsequently inhibit the mevalonate pathway and cholesterol synthesis. Since cholesterol trafficking is vital in the growth and metastasis of cancer, statin drugs are being studied to explore their effects on cancer cells. CoQ10, one of the products from the mevalonate pathway, also has shown some potential anti-cancer properties, but its use to combat cancer is controversial. While some studies have shown that CoQ10 supplements can be synergistic with other cancer treatment methods, the biochemical mechanisms of CoQ10’s potential anti-cancer properties are poorly understood. In this experiment, the anti-cancer potentials of lovastatin and CoQ10 were studied using the breast cancer cell lines BoM-1833 (BoM) derived from MDA-231, MCF7/BoM, and T47D. The IC50 values for lovastatin were found to be 4.89×10-06 M (BoM) and 4.06×10-06 M (MCF7/BoM). The IC50 values for CoQ10 were found to be 5.46×10-07 M (BoM) and 8.86×10-07 M (MCF7/BoM). IC50 values for lovastatin and CoQ10 with the cell line T47D were not found because the drugs did not sufficiently inhibit the growth of the T47D cells.

Item Type: Thesis (Undergraduate)
Uncontrolled Keywords: metastatic breast cancer, breast cancer, lovastatin, statin, CoQ10, T47D, BoM, MCF7, MDA-MB-213, metastasis, bone metastasis
Creators: Thrasher, Jacob
Student's Degree Program(s): BS Chemistry (Biochemistry emphasis)
Thesis Advisor: Yu-Dong Zhou and Dale Nagle
Thesis Advisor's Department: Chemistry and Biochemistry and BioMolecular Sciences
Institution: University of Mississippi
Subjects: Q Science > QD Chemistry
Depositing User: Jake Thrasher
Date Deposited: 14 May 2018 13:23
Last Modified: 14 May 2018 13:23
URI: http://thesis.honors.olemiss.edu/id/eprint/1180

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