O-GLCNAC Post Translational Modification of Hypoxia-Inducible Factor (HIF) Proteins

Grisham, Hailey Elisabeth (2018) O-GLCNAC Post Translational Modification of Hypoxia-Inducible Factor (HIF) Proteins. Undergraduate thesis, under the direction of Yu-Dong Zhou and Dale Nagle from Chemistry and Biochemistry and BioMolecular Sciences, The University of Mississippi.

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Abstract

O-linked β-N-acetylglucosamine (O-GlcNAc) post-translational modification (O- GlcNAcylation), plays a vital role in many metabolic pathways, including those of numerous diseases. New research methods and basic functional roles of O-GlcNAc post- translational modification on metabolism, human health, and cancer are quickly developing, but a vast amount of research remains on the specificity of this pathway towards specific proteins. In this study, T47D breast cancer cells were used as an in vitro model to investigate the effects of O-GlcNAc modification on hypoxia-inducible factor (HIF) proteins.

Item Type: Thesis (Undergraduate)
Creators: Grisham, Hailey Elisabeth
Student's Degree Program(s): General Engineering
Thesis Advisor: Yu-Dong Zhou and Dale Nagle
Thesis Advisor's Department: Chemistry and Biochemistry and BioMolecular Sciences
Institution: The University of Mississippi
Subjects: Q Science > QD Chemistry
Depositing User: Hailey Hailey Grisham
Date Deposited: 04 May 2018 17:07
Last Modified: 04 May 2018 17:07
URI: http://thesis.honors.olemiss.edu/id/eprint/1035

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